![]() 1 for patient exclusion details and Table 1 for patient characteristics in the eligible cohort and included cohort). By providing better prediction of response, MRI can advance personalized treatment and play an important role in assessing whether to change targeted therapies or proceed directly to surgical resection.Ī total of 384 patients who had complete MRI data and pCR outcome were included in the analysis (see Fig. This study investigated whether the predictive performance of MRI can be improved over FTV or any single feature alone by using a combination of features measured on DCE-MRI. Several studies have shown the association of BPE with breast cancer risk in the screening setting, and decreased BPE has been found to be associated with pCR following neoadjuvant chemotherapy 12, 13, 14, 16, 17. Sphericity is a three-dimensional shape feature previously found to be associated with pCR in the I-SPY2 trial 11. Longest diameter is a standard clinical measurement used to assess tumor response, consistent with the Response Evaluation Criteria in Solid Tumors (RECIST) 15. These additional measures have also shown value for prediction of pCR 11, 12, 13, 14. Additional features can be derived from the same DCE-MRI data, including longest diameter, sphericity, and contralateral background parenchymal enhancement (BPE). While FTV has shown effectiveness for the prediction of pCR, there is still potential for improvement, especially in the setting of hormone-positive tumors 10. Pathologic complete response is the primary endpoint in I-SPY 2.įTV represents the active portion of tumor volume, as defined by pharmacokinetic thresholds applied to dynamic contrast-enhanced MRI (DCE-MRI) 9. Subsequently, serial measures of FTV during treatment are used in the adaptive randomization engine of the I-SPY 2 trial, designed to accelerate the evaluation of novel agents for breast cancer 8. Results from the I-SPY 1 TRIAL (CALGB 150007/ACRIN 6657) found that functional tumor volume (FTV) predicted pathologic complete response (pCR) and recurrence-free survival 6, 7. Among imaging methods, magnetic resonance imaging (MRI) is the most accurate for assessing tumor response to NAC 1, 2, 3, 4, 5. Additionally, the improvements in prediction were more notable when analysis was conducted according to cancer subtype.Īn important advantage of neoadjuvant chemotherapy (NAC) over adjuvant therapy for locally advanced breast cancer is the ability to monitor treatment response, which allows informed adjustment of the treatment plan. Multi-feature MRI analysis improved pCR prediction over analysis of any individual feature that we examined. Results showed analysis with combined features achieved higher AUCs than analysis with any feature alone. A total of 384 patients (median age: 49 y/o) were included. The full cohort was stratified by hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status (positive or negative). Predictive performance was estimated using the area under the receiver operating characteristic curve (AUC). Logistic regression analysis was used to study the relationship between MRI variables and pathologic complete response (pCR). Four features were quantitatively calculated in each MRI exam: functional tumor volume, longest diameter, sphericity, and contralateral background parenchymal enhancement. The purpose of this retrospective study is to test if prediction models combining multiple MRI features outperform models with single features. Npj Breast Cancer volume 6, Article number: 63 ( 2020)ĭynamic contrast-enhanced (DCE) MRI provides both morphological and functional information regarding breast tumor response to neoadjuvant chemotherapy (NAC). ![]() Predicting breast cancer response to neoadjuvant treatment using multi-feature MRI: results from the I-SPY 2 TRIAL
0 Comments
![]() Boom Chicka Boom is an interactive music and movement song. Narrator: BOOM BOOM! Coming to theaters everywhere in June. With more than 20 million books sold, Chicka Chicka Boom Boom is one of the best selling childrens books of all time and has remained a childrens. Boom Chicka Boom by Jack Hartmann is an old favorite with new movements and characters. Narrator: …only to see it turn into a nightmare.Ī and b ’s peaceful moment is interrupted by a slight tremor that rapidly starts to increase in magnitude. Narrator: … as one letter finally achieves his dream…ĬUT TO a and b at the top of the coconut tree.Ī: Would you look at that view? It’s even more beautiful than I imagined.ī: I still can’t believe we’re really here. The letters break out into raucous cheering as a begins his ascent, quickly followed by b, c, and the rest of the alphabet. Narrator: … prepare to go on an adventure of dictionarial proportions…ĬUT TO the alphabet gathering at the base of the coconut tree. But if we work together and go up one at a time in alphabetical order, I guarantee you that all twenty-six of us can make it to the top of that coconut tree!ĬUT TO a and b ’s fathers A and B having a tense discussion in their office.ī: Do you know what your son is up to right now?ī: He is rallying the whole alphabet to go on a suicide mission! You’ve got to put a stop to this!Ī: Don’t you think I know that?! But my son has been obsessed with that coconut tree for years! Anything I say to discourage him is just going to make him want to go up it more! The only way he moves on…( A pauses and starts to choke up) is if he goes up that tree. We are going to find out what’s at the top of that coconut tree.ĬUT TO a rallying the rest of the alphabet inside his clubhouse.Ī: It might not be easy. And I swear, b, I just can’t wait any longer.Ī grabs b by the shoulders and turns him so that they’re facing each other.Ī: It happens today. ![]() He chuckles softly to himself while gazing up.ĬUT TO a and his best friend, b, strolling along the beach.Ī: The weather is perfect. The camera slowly pans down from the top, and we see our hero, a, at its trunk. We hear birds in the distance and see images of the island’s iconic landscape: A volcano. Is there anything more iconic than a Chicka Chicka Boom Boom week in Kindergarten This is one of my favorite weeks of all time because it gets my students. To learn more about how and for what purposes Amazon uses personal information (such as Amazon Store order history), please visit our Privacy Notice.The sun rises over a picturesque tropical island. You can change your choices at any time by visiting Cookie Preferences, as described in the Cookie Notice. Click ‘Customise Cookies’ to decline these cookies, make more detailed choices, or learn more. Third parties use cookies for their purposes of displaying and measuring personalised ads, generating audience insights, and developing and improving products. This includes using first- and third-party cookies, which store or access standard device information such as a unique identifier. The illustrations of the patched-up letters are whimsical and endearing. 'Chicka chicka boom boom' becomes a fun mantra for children, who shout it out as an 'Uh-oh' to warn the adventurous alphabet characters. If you agree, we’ll also use cookies to complement your shopping experience across the Amazon stores as described in our Cookie Notice. The dazzling rainbow parade of colorful letters make them memorable, adding to the educational value of this rhyming tale. We also use these cookies to understand how customers use our services (for example, by measuring site visits) so we can make improvements. ![]() ![]() We use cookies and similar tools that are necessary to enable you to make purchases, to enhance your shopping experiences and to provide our services, as detailed in our Cookie Notice. |